Role of sphingomyelin-MAPKs pathway in heat-induced apoptosis
نویسندگان
چکیده
منابع مشابه
Stress-induced apoptosis and the sphingomyelin pathway.
The sphingomyelin pathway is a ubiquitous, evolutionarily conserved signaling system initiated by hydrolysis of the plasma membrane phospholipid sphingomyelin to generate the second messenger ceramide. Sphingomyelin degradation is catalyzed by acid and neutral sphingomyelinase (SMase) isoforms. Most, if not all mammalian cells, appear capable of signaling though the sphingomyelin pathway. Diver...
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BACKGROUND AND OBJECT Cell apoptosis is a contributing factor in the initiation, progression and relapse of atrial fibrillation (AF), a life-threatening illness accompanied with stroke and heart failure. However, the regulatory cascade of apoptosis is intricate and remains unidentified, especially in the setting of AF. The aim of this study was to explore the roles of endoplasmic reticulum (ER)...
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ژورنال
عنوان ژورنال: Experimental & Molecular Medicine
سال: 2003
ISSN: 2092-6413
DOI: 10.1038/emm.2003.25